KMID : 0617319930030010068
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Journal of Pharmacetical Sceiences Ewha Womans University 1993 Volume.3 No. 1 p.68 ~ p.73
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Ring Transformation Reaction of Thiazolo[3,2-a][1,3]diazepinium-Betaine
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Abstract
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3-Phenyl-5,6,7,8-tetrahydrothiazolo[3,2-¥á][1,3] diazepine, which has pharmaceutical activities, was reacted with phenyl isothiocyanate to give 3-phenyl-9-phenyl(thiocarbamoyl)-5,6,7,8-tet-rahydrothiazolo[3,2-¥á][1,3]diazepinium-betaine. New biheterocyclic compounds were prepared by the ring transformation reaction of the above reactive betaine with ¥á-haloesters and ¥á-haloketones such as ethyl bromoacetate, methyl bromoacetate, chloroacetone, and 4¡Ç-methoxyphenacyl bromide, respectively, In each ring transformation reaction, two major products supposed to be geometrical isomers were obtained.
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